Trametenolic acid
Appearance
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Names | |
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IUPAC name
3β-Hydroxylanosta-8,24-dien-21-oic acid
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Systematic IUPAC name
(2R)-2-[(1R,3aR,5aR,7S,9aS,11aR)-7-Hydroxy-3a,6,6,9a,11a-pentamethyl-2,3,3a,4,5,5a,6,7,8,9,9a,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-enoic acid | |
Identifiers | |
3D model (JSmol)
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C30H48O3 | |
Molar mass | 456.711 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Trametenolic acid is an anti-inflammatory sterol isolated from Inonotus obliquus.[1] Duan et al reported that Trametenolic Acid had exhibited protective effect on the kidneys and ameliorated the progression of Diabetic Nephropathy in db/db Mice (The db/db mice are perfect animal models of type 2 diabetes.) via Nrf2/HO-1 and NF-κB-Mediated Pathways [2] Trametenolic Acid Mitigated Oxidative Stress in animal studies
References
[edit]- ^ Ma, L; Chen, H; Dong, P; Lu, X (2013). "Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus". Food Chemistry. 139 (1–4): 503–8. doi:10.1016/j.foodchem.2013.01.030. PMID 23561137.
- ^ Duan Q, Tian L, Feng J, Ping X, Li L, Yaigoub H, Li R, Li Y. Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways. J Immunol Res. 2022 Aug 30;2022:6151847. doi: 10.1155/2022/6151847. PMID: 36081452; PMCID: PMC9448586}}